Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB
نویسندگان
چکیده
منابع مشابه
Aberrant activity of the DNA repair enzyme AlkB.
Escherichia coli AlkB is a DNA/RNA repair enzyme containing a mononuclear Fe(II) site that couples the oxidative decomposition of alpha-ketoglutarate (alphaKG) to the hydroxylation of 1-methyladenine or 3-methylcytosine lesions in DNA or RNA, resulting in release of formaldehyde and restoration of the normal bases. In the presence of Fe(II), alphaKG, and oxygen, but the absence of methylated DN...
متن کاملDynamic states of the DNA repair enzyme AlkB regulate product release.
The 2-oxoglutarate (2OG)- and Fe(2+)-dependent dioxygenase AlkB couples the demethylation of modified DNA to the decarboxylation of 2OG. Extensive crystallographic analyses have shown no evidence of significant structural differences between complexes binding either 2OG or succinate. By using nuclear magnetic resonance spectroscopy, we have shown that the AlkB-succinate and AlkB-2OG complexes h...
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the rationale behind the present study is that particular learning strategies produce more effective results when applied together. the present study tried to investigate the efficiency of the semantic-context strategy alone with a technique called, keyword method. to clarify the point, the current study seeked to find answer to the following question: are the keyword and semantic-context metho...
15 صفحه اولDirect repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.
The exocyclic DNA base adduct 1,N6-ethenoadenine (epsilonA) is directly repaired by the AlkB proteins in vitro.
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2003
ISSN: 1471-2164
DOI: 10.1186/1471-2164-4-48